Analysis Note

ControlBrainHippocampal tissue

Application

Immunohistochemistry: A previous lot of this antibody was used in IH.

Optimal working dilutions must be determined by end user.

Anti-Glutamate Receptor 3 Antibody, clone 3B3 is an antibody against Glutamate Receptor 3 for use in WB, IC, IH, IH(P).

General description

AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition.There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling. Millipore's anti-GluR2/3 antibody is useful for localizing expression of GluR2/GluR3 receptor assemblies in the PSD.

Immunogen

Fusion protein, N-terminus of GluR3

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Liquid in PBS. Contains no preservative.

Quality

Western Blot Analysis: A previous lot of this antibody was used in WB.

Specificity

Reacts with Glutamate Receptor 3 (GluR3). No cross reactivity with GluR2.

Target description

~ 110 kDa